Purpose: This paper is a review of wetting contact angle definition and measurement, wettability of contact lens, impact of tear film and contact lens solution on wetting angle. Also, the clinical performance of these parameters will be discussed. Methods: For this review article, the data about contact lens wettability and wetting angle published in the PubMed were used. Based on inclusion (publication year between 1975 and 2017, relevance to the title and the field of study, key references) and exclusion (dissimilarity to the topics) criteria, 66 articles were studied carefully. Conclusion: Several parameters including oxygen permeability, lens material, edge design, lens rigidity, lens thickness, and surface treatment methods are effective on patient`s comfortability. If all these factors are assumed to be under control and are not subject to any changes, wettability as a variable could be an important factor contributing to patient comfort. The relationships between the contact lens wetting angle, wettability, and comfortability considering multiple factors, are controversial that need more research in this field.